1 (of a building or place) in very bad condition; that has not been looked after
SYNNEGLECTED:
run-down inner-city areas
2 (of a business, etc.) not as busy or as active as it used to be:
run-down transport services
3 [notbeforenoun] (of a person) tired or slightly ill/sick, especially from working hard:
to be / feel / get run-down
